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1Z1R

HIV-1 protease complexed with Macrocyclic peptidomimetic inhibitor 2

Replaces:  1B6O
Summary for 1Z1R
Entry DOI10.2210/pdb1z1r/pdb
Related1B6J 1B6K 1B6L 1B6M 1B6N 1B6O 1B6P
DescriptorPol polyprotein, SULFATE ION, 2-[(8S,11S)-11-{(1R)-1-HYDROXY-2-[ISOPENTYL(PHENYLSULFONYL)AMINO]ETHYL}-6,9-DIOXO-2-OXA-7,10-DIAZABICYCLO[11.2.2]HEPTADECA-1(15),13,16-TRIEN-8-YL]ACETAMIDE, ... (4 entities in total)
Functional Keywordsmacrocyclic inhibitors, peptidomimetic inhibitors, hiv1 protease, hydrolase
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03369
Total number of polymer chains2
Total formula weight22408.28
Authors
Primary citationMartin, J.L.,Begun, J.,Schindeler, A.,Wickramasinghe, W.A.,Alewood, D.,Alewood, P.F.,Bergman, D.A.,Brinkworth, R.I.,Abbenante, G.,March, D.R.,Reid, R.C.,Fairlie, D.P.
Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease
Biochemistry, 38:7978-7988, 1999
Cited by
PubMed: 10387041
DOI: 10.1021/bi990174x
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.85 Å)
Structure validation

217705

数据于2024-03-27公开中

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