1Z1R

HIV-1 protease complexed with Macrocyclic peptidomimetic inhibitor 2

「1B6O」から置き換えられました

1Z1R の概要

• エントリーDOI: 10.2210/pdb1z1r/pdb
• 関連するPDBエントリー: 1B6J 1B6K 1B6L 1B6M 1B6N 1B6O 1B6P
• 分子名称: Pol polyprotein, SULFATE ION, 2-[(8S,11S)-11-{(1R)-1-HYDROXY-2-[ISOPENTYL(PHENYLSULFONYL)AMINO]ETHYL}-6,9-DIOXO-2-OXA-7,10-DIAZABICYCLO[11.2.2]HEPTADECA-1(15),13,16-TRIEN-8-YL]ACETAMIDE, ... (4 entities in total)
• 機能のキーワード: macrocyclic inhibitors, peptidomimetic inhibitors, hiv1 protease, hydrolase
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03369
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22408.28

構造登録者

Martin, J.L.,Begun, J.,Schindeler, A.,Wickramasinghe, W.A.,Alewood, D.,Alewood, P.F.,Bergman, D.A.,Brinkworth, R.I.,Abbenante, G.,March, D.R.,Reid, R.C.,Fairlie, D.P. (登録日: 2005-03-06, 公開日: 2005-03-22, 最終更新日: 2023-11-15)

• 主引用文献: Martin, J.L.,Begun, J.,Schindeler, A.,Wickramasinghe, W.A.,Alewood, D.,Alewood, P.F.,Bergman, D.A.,Brinkworth, R.I.,Abbenante, G.,March, D.R.,Reid, R.C.,Fairlie, D.P.; Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease; Biochemistry, 38:7978-7988, 1999; PubMed: 10387041; DOI: 10.1021/bi990174x

実験手法

X-RAY DIFFRACTION (1.85 Å)