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1Z1C

Structural Determinants of Tissue Tropism and In Vivo Pathogenicity for the Parvovirus Minute virus of Mice

1Z1C の概要
エントリーDOI10.2210/pdb1z1c/pdb
関連するPDBエントリー1MVM 1Z14
分子名称5'-D(*AP*TP*CP*CP*TP*CP*TP*AP*TP*CP*AP*C)-3', 5'-D(*AP*CP*AP*CP*CP*AP*AP*AP*A)-3', Coat protein VP2, ... (6 entities in total)
機能のキーワードimmunosuppressive strain, mvmi, minute virus of mice, icosahedral virus, virus-dna complex, virus/dna
由来する生物種Murine minute virus (STRAIN MVMI)
細胞内の位置Virion : P07302
タンパク質・核酸の鎖数3
化学式量合計71416.15
構造登録者
主引用文献Kontou, M.,Govindasamy, L.,Nam, H.J.,Bryant, N.,Llamas-Saiz, A.L.,Foces-Foces, C.,Hernando, E.,Rubio, M.P.,McKenna, R.,Almendral, J.M.,Agbandje-McKenna, M.
Structural determinants of tissue tropism and in vivo pathogenicity for the parvovirus minute virus of mice.
J.Virol., 79:10931-10943, 2005
Cited by
PubMed Abstract: Two strains of the parvovirus minute virus of mice (MVM), the immunosuppressive (MVMi) and the prototype (MVMp) strains, display disparate in vitro tropism and in vivo pathogenicity. We report the crystal structures of MVMp virus-like particles (MVMp(b)) and native wild-type (wt) empty capsids (MVMp(e)), determined and refined to 3.25 and 3.75 A resolution, respectively, and their comparison to the structure of MVMi, also refined to 3.5 A resolution in this study. A comparison of the MVMp(b) and MVMp(e) capsids showed their structures to be the same, providing structural verification that some heterologously expressed parvovirus capsids are indistinguishable from wt capsids produced in host cells. The structures of MVMi and MVMp capsids were almost identical, but local surface conformational differences clustered from symmetry-related capsid proteins at three specific domains: (i) the icosahedral fivefold axis, (ii) the "shoulder" of the protrusion at the icosahedral threefold axis, and (iii) the area surrounding the depression at the icosahedral twofold axis. The latter two domains contain important determinants of MVM in vitro tropism (residues 317 and 321) and forward mutation residues (residues 399, 460, 553, and 558) conferring fibrotropism on MVMi. Furthermore, these structural differences between the MVM strains colocalize with tropism and pathogenicity determinants mapped for other autonomous parvovirus capsids, highlighting the importance of common parvovirus capsid regions in the control of virus-host interactions.
PubMed: 16103145
DOI: 10.1128/JVI.79.17.10931-10943.2005
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (3.5 Å)
構造検証レポート
Validation report summary of 1z1c
検証レポート(詳細版)ダウンロードをダウンロード

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件を2025-07-09に公開中

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