1YZ3
Structure of human pnmt complexed with cofactor product adohcy and inhibitor SK&F 64139
Summary for 1YZ3
Entry DOI | 10.2210/pdb1yz3/pdb |
Related | 1HNN 1N7I 1N7J |
Descriptor | Phenylethanolamine N-methyltransferase, 7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE, S-ADENOSYL-L-HOMOCYSTEINE, ... (4 entities in total) |
Functional Keywords | enzyme, product, inhibitor complex, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 64864.92 |
Authors | Wu, Q.,Gee, C.L.,Lin, F.,Martin, J.L.,Grunewald, G.L.,McLeish, M.J. (deposition date: 2005-02-27, release date: 2006-02-07, Last modification date: 2023-10-25) |
Primary citation | Wu, Q.,Gee, C.L.,Lin, F.,Tyndall, J.D.,Martin, J.L.,Grunewald, G.L.,McLeish, M.J. Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase J.Med.Chem., 48:7243-7252, 2005 Cited by PubMed: 16279783DOI: 10.1021/jm050568o PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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