1YZ3

Structure of human pnmt complexed with cofactor product adohcy and inhibitor SK&F 64139

1YZ3 の概要

• エントリーDOI: 10.2210/pdb1yz3/pdb
• 関連するPDBエントリー: 1HNN 1N7I 1N7J
• 分子名称: Phenylethanolamine N-methyltransferase, 7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE, S-ADENOSYL-L-HOMOCYSTEINE, ... (4 entities in total)
• 機能のキーワード: enzyme, product, inhibitor complex, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 64864.92

構造登録者

Wu, Q.,Gee, C.L.,Lin, F.,Martin, J.L.,Grunewald, G.L.,McLeish, M.J. (登録日: 2005-02-27, 公開日: 2006-02-07, 最終更新日: 2023-10-25)

• 主引用文献: Wu, Q.,Gee, C.L.,Lin, F.,Tyndall, J.D.,Martin, J.L.,Grunewald, G.L.,McLeish, M.J.; Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase; J.Med.Chem., 48:7243-7252, 2005; PubMed: 16279783; DOI: 10.1021/jm050568o

実験手法

X-RAY DIFFRACTION (2.4 Å)