1YXS

Crystal Structure of Kinase Pim1 with P123M mutation

Summary for 1YXS

Related1YWV 1YXT 1YXU 1YXX 1YXV
DescriptorProto-oncogene serine/threonine-protein kinase Pim-1, IMIDAZOLE (3 entities in total)
Functional Keywordsser/thr protein kinase, transferase
Biological sourceHomo sapiens (human)
Cellular locationIsoform 2: Cytoplasm. Isoform 1: Cell membrane P11309
Total number of polymer chains1
Total molecular weight33935.49
Authors
Kumar, A.,Mandiyan, V.,Suzuki, Y.,Zhang, C.,Rice, J.,Tsai, J.,Artis, D.R.,Ibrahim, P.,Bremer, R. (deposition date: 2005-02-22, release date: 2005-04-26, Last modification date: 2015-06-24)
Primary citation
Kumar, A.,Mandiyan, V.,Suzuki, Y.,Zhang, C.,Rice, J.,Tsai, J.,Artis, D.R.,Ibrahim, P.,Bremer, R.
Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma.
J.Mol.Biol., 348:183-193, 2005
PubMed: 15808862 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2005.02.039
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24741.5%5.3%7.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution