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1YW8

h-MetAP2 complexed with A751277

Summary for 1YW8
Entry DOI10.2210/pdb1yw8/pdb
Related1YW7 1YW9
DescriptorMethionine aminopeptidase 2, MANGANESE (II) ION, 2-[(PHENYLSULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID, ... (4 entities in total)
Functional Keywordshydrolase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight41811.27
Authors
Park, C.H. (deposition date: 2005-02-17, release date: 2006-02-21, Last modification date: 2011-07-13)
Primary citationSheppard, G.S.,Wang, J.,Kawai, M.,Fidanze, S.D.,BaMaung, N.Y.,Erickson, S.A.,Barnes, D.M.,Tedrow, J.S.,Kolaczkowski, L.,Vasudevan, A.,Park, D.C.,Wang, G.T.,Sanders, W.J.,Mantei, R.A.,Palazzo, F.,Tucker-Garcia, L.,Lou, P.,Zhang, Q.,Park, C.H.,Kim, K.H.,Petros, A.,Olejniczak, E.,Nettesheim, D.,Hajduk, P.,Henkin, J.,Lesniewski, R.,Davidsen, S.K.,Bell, R.L.
Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding.
J.Med.Chem., 49:3832-3849, 2006
Cited by
PubMed: 16789740
DOI: 10.1021/jm0601001
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.65 Å)
Structure validation

217705

数据于2024-03-27公开中

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