1YVZ
Hepatitis C Virus RNA Polymerase Genotype 2a In Complex With Non- Nucleoside Analogue Inhibitor
Summary for 1YVZ
Entry DOI | 10.2210/pdb1yvz/pdb |
Related | 1YUY 1YVX |
Descriptor | RNA dependent RNA polymerase, SULFATE ION, 3-[(2,4-DICHLOROBENZOYL)(ISOPROPYL)AMINO]-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID, ... (4 entities in total) |
Functional Keywords | ns5b polymerase genotype 2a, non-nucleoside inhibitor, viral protein |
Biological source | Hepatitis C virus |
Cellular location | Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : P26660 |
Total number of polymer chains | 1 |
Total formula weight | 64482.48 |
Authors | Biswal, B.K.,Cherney, M.M.,Wang, M.,Chan, L.,Yannopoulos, C.G.,Bilimoria, D.,Nicolas, O.,Bedard, J.,James, M.N.G. (deposition date: 2005-02-16, release date: 2005-03-22, Last modification date: 2017-10-11) |
Primary citation | Biswal, B.K.,Cherney, M.M.,Wang, M.,Chan, L.,Yannopoulos, C.G.,Bilimoria, D.,Nicolas, O.,Bedard, J.,James, M.N.G. Crystal structures of the RNA dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors. J.Biol.Chem., 280:18202-18210, 2005 Cited by PubMed: 15746101DOI: 10.1074/jbc.M413410200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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