1YPZ

Immune receptor

1YPZ の概要

• エントリーDOI: 10.2210/pdb1ypz/pdb
• 分子名称: H2-T22 protein, Beta-2-microglobulin, T cell receptor delta, ... (7 entities in total)
• 機能のキーワード: h2-t22 protein, beta-2-microglobulin, t cell receptor delta, t-cell receptor gamma chain, immune system
• 由来する生物種: Mus musculus (house mouse); 詳細
• 細胞内の位置: Secreted: P61769
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 184680.92

構造登録者

Adams, E.J.,Garcia, K.C. (登録日: 2005-01-31, 公開日: 2005-04-12, 最終更新日: 2024-12-25)

主引用文献

Adams, E.J.,Chien, Y.H.,Garcia, K.C.
Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22.
Science, 308:227-231, 2005

PubMed Abstract: Gammadelta T cell receptors (TCRs), alphabeta TCRs, and antibodies are the three lineages of somatically recombined antigen receptors. The structural basis for ligand recognition is well defined for alphabeta TCR and antibodies but is lacking for gammadelta TCRs. We present the 3.4 A structure of the murine gammadelta TCR G8 bound to its major histocompatibility complex (MHC) class Ib ligand, T22. G8 predominantly uses germline-encoded residues of its delta chain complementarity-determining region 3 (CDR3) loop to bind T22 in an orientation substantially different from that seen in alphabeta TCR/peptide-MHC. That junctionally encoded G8 residues play an ancillary role in binding suggests a fusion of innate and adaptive recognition strategies.

PubMed: 15821084
DOI: 10.1126/science.1106885

実験手法

X-RAY DIFFRACTION (3.4 Å)