1YPQ

Human Oxidized Low Density Lipoprotein Receptor LOX-1 Dioxane Complex

1YPQ の概要

• エントリーDOI: 10.2210/pdb1ypq/pdb
• 関連するPDBエントリー: 1YPO 1YPU
• 分子名称: oxidised low density lipoprotein (lectin-like) receptor 1, 1,4-DIETHYLENE DIOXIDE (3 entities in total)
• 機能のキーワード: oxidized low density lipoprotein receptor, lox-1, ctld, c-type lectin like domain, nk cell receptor, immune system
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Single-pass type II membrane protein: P78380
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30712.87

構造登録者

Park, H.,Adsit, F.G.,Boyington, J.C. (登録日: 2005-01-31, 公開日: 2005-02-08, 最終更新日: 2024-11-06)

主引用文献

Park, H.,Adsit, F.G.,Boyington, J.C.
The 1.4 angstrom crystal structure of the human oxidized low density lipoprotein receptor lox-1.
J.Biol.Chem., 280:13593-13599, 2005

PubMed Abstract: The lectin-like oxidized low density lipoprotein receptor-1 (Lox-1) mediates the recognition and internalization of oxidatively modified low density lipoprotein by vascular endothelial cells. This interaction results in a number of pro-atherogenic cellular responses that probably play a significant role in the pathology of atherosclerosis. The 1.4 angstrom crystal structure of the extracellular C-type lectin-like domain of human Lox-1 reveals a heart-shaped homodimer with a ridge of six basic amino acids extending diagonally across the apolar top of Lox-1, a central hydrophobic tunnel that extends through the entire molecule, and an electrostatically neutral patch of 12 charged residues that resides next to the tunnel at each opening. Based on the arrangement of critical binding residues on the Lox-1 structure, we propose a binding mode for the recognition of modified low density lipoprotein and other Lox-1 ligands.

PubMed: 15695803
DOI: 10.1074/jbc.M500768200

実験手法

X-RAY DIFFRACTION (1.4 Å)