1YOU

Crystal structure of the catalytic domain of MMP-13 complexed with a potent pyrimidinetrione inhibitor

Summary for 1YOU

• Entry DOI: 10.2210/pdb1you/pdb
• Descriptor: Collagenase 3, ZINC ION, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: hydrolase, metalloprotease
• Biological source: Homo sapiens (human)
• Cellular location: Secreted, extracellular space, extracellular matrix (Probable): P45452
• Total number of polymer chains: 2
• Total formula weight: 39252.88

Authors

Pandit, J. (deposition date: 2005-01-28, release date: 2005-03-15, Last modification date: 2023-08-23)

• Primary citation: Blagg, J.A.,Noe, M.C.,Wolf-Gouveia, L.A.,Reiter, L.A.,Laird, E.R.,Chang, S.P.,Danley, D.E.,Downs, J.T.,Elliott, N.C.,Eskra, J.D.,Griffiths, R.J.,Hardink, J.R.,Haugeto, A.I.,Jones, C.S.,Liras, J.L.,Lopresti-Morrow, L.L.,Mitchell, P.G.,Pandit, J.,Robinson, R.P.,Subramanyam, C.,Vaughn-Bowser, M.L.,Yocum, S.A.; Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14.; Bioorg.Med.Chem.Lett., 15:1807-1810, 2005; PubMed: 15780611; DOI: 10.1016/j.bmcl.2005.02.038

Experimental method

X-RAY DIFFRACTION (2.3 Å)