1YOK
crystal structure of human LRH-1 bound with TIF-2 peptide and phosphatidylglycerol
Summary for 1YOK
Entry DOI | 10.2210/pdb1yok/pdb |
Related | 1YMT |
Descriptor | Orphan nuclear receptor NR5A2, Nuclear receptor coactivator 2, (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE, ... (4 entities in total) |
Functional Keywords | lrh-1, tif-1, phosphatidylglycerol, transcription |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus (Probable): O00482 Nucleus: Q15596 |
Total number of polymer chains | 3 |
Total formula weight | 33965.38 |
Authors | Krylova, I.N.,Sablin, E.P.,Moore, J.,Xu, R.X.,Waitt, G.M.,MacKay, J.A.,Juzumiene, D.,Bynum, J.M.,Madauss, K.,Montana, V.,Lebedeva, L.,Suzawa, M.,Williams, J.D.,Williams, S.P.,Guy, R.K.,Thornton, J.W.,Fletterick, R.J.,Willson, T.M.,Ingraham, H.A. (deposition date: 2005-01-27, release date: 2005-07-19, Last modification date: 2024-04-03) |
Primary citation | Krylova, I.N.,Sablin, E.P.,Moore, J.,Xu, R.X.,Waitt, G.M.,MacKay, J.A.,Juzumiene, D.,Bynum, J.M.,Madauss, K.,Montana, V.,Lebedeva, L.,Suzawa, M.,Williams, J.D.,Williams, S.P.,Guy, R.K.,Thornton, J.W.,Fletterick, R.J.,Willson, T.M.,Ingraham, H.A. Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Cell(Cambridge,Mass.), 120:343-355, 2005 Cited by PubMed: 15707893DOI: 10.1016/j.cell.2005.01.024 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
Download full validation report