1YOK

crystal structure of human LRH-1 bound with TIF-2 peptide and phosphatidylglycerol

Summary for 1YOK

• Entry DOI: 10.2210/pdb1yok/pdb
• Related: 1YMT
• Descriptor: Orphan nuclear receptor NR5A2, Nuclear receptor coactivator 2, (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE, ... (4 entities in total)
• Functional Keywords: lrh-1, tif-1, phosphatidylglycerol, transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus (Probable): O00482; Nucleus: Q15596
• Total number of polymer chains: 3
• Total formula weight: 33965.38

Authors

Krylova, I.N.,Sablin, E.P.,Moore, J.,Xu, R.X.,Waitt, G.M.,MacKay, J.A.,Juzumiene, D.,Bynum, J.M.,Madauss, K.,Montana, V.,Lebedeva, L.,Suzawa, M.,Williams, J.D.,Williams, S.P.,Guy, R.K.,Thornton, J.W.,Fletterick, R.J.,Willson, T.M.,Ingraham, H.A. (deposition date: 2005-01-27, release date: 2005-07-19, Last modification date: 2024-04-03)

• Primary citation: Krylova, I.N.,Sablin, E.P.,Moore, J.,Xu, R.X.,Waitt, G.M.,MacKay, J.A.,Juzumiene, D.,Bynum, J.M.,Madauss, K.,Montana, V.,Lebedeva, L.,Suzawa, M.,Williams, J.D.,Williams, S.P.,Guy, R.K.,Thornton, J.W.,Fletterick, R.J.,Willson, T.M.,Ingraham, H.A.; Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.; Cell(Cambridge,Mass.), 120:343-355, 2005; PubMed: 15707893; DOI: 10.1016/j.cell.2005.01.024

Experimental method

X-RAY DIFFRACTION (2.5 Å)