1YK8

Cathepsin K complexed with a cyanamide-based inhibitor

1YK8 の概要

• エントリーDOI: 10.2210/pdb1yk8/pdb
• 分子名称: Cathepsin K, TERT-BUTYL 2-CYANO-2-METHYLHYDRAZINECARBOXYLATE (3 entities in total)
• 機能のキーワード: catk, cathepsin, cysteine, protease, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Lysosome: P43235
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23694.68

構造登録者

Barrett, D.G.,Deaton, D.N.,Hassell, A.M.,McFadyen, R.B.,Miller, A.B.,Miller, L.R.,Payne, J.A.,Shewchuk, L.M.,Willard, D.H.,Wright, L.L. (登録日: 2005-01-17, 公開日: 2005-07-19, 最終更新日: 2024-11-06)

主引用文献

Barrett, D.G.,Deaton, D.N.,Hassell, A.M.,McFadyen, R.B.,Miller, A.B.,Miller, L.R.,Payne, J.A.,Shewchuk, L.M.,Willard, D.H.,Wright, L.L.
Acyclic cyanamide-based inhibitors of cathepsin K.
Bioorg.Med.Chem.Lett., 15:3039-3043, 2005

PubMed Abstract: Conversion of the proline-derived cyanamide lead to an acyclic cyanamide capable of forming an additional hydrogen bond with cathepsin K resulted in a large increase in inhibitory activity. An X-ray structure of a co-crystal of a cyanamide with cathepsin K confirmed the enzyme interaction. Furthermore, a representative acyclic cyanamide inhibitor 6r was able to attenuate bone resorption in the rat calvarial model.

PubMed: 15896958
DOI: 10.1016/j.bmcl.2005.04.032

実験手法

X-RAY DIFFRACTION (2.6 Å)