1YJD

Crystal structure of human CD28 in complex with the Fab fragment of a mitogenic antibody (5.11A1)

Summary for 1YJD

Entry DOI	10.2210/pdb1yjd/pdb
Descriptor	Fab fragment of 5.11A1 antibody light chain, Fab fragment of 5.11A1 antibody heavy chain, T-cell-specific surface glycoprotein CD28, ... (5 entities in total)
Functional Keywords	igsf, cd28 homodimer, immune system-signaling protein complex, immune system/signaling protein
Biological source	Homo sapiens (human) More
Cellular location	Membrane; Single-pass type I membrane protein: P10747
Total number of polymer chains	3
Total formula weight	63945.46
Authors	Evans, E.J.,Esnouf, R.M.,Manso-Sancho, R.,Gilbert, R.J.C.,James, J.R.,Sorensen, P.,Stuart, D.I.,Davis, S.J. (deposition date: 2005-01-14, release date: 2005-02-15, Last modification date: 2020-07-29)
Primary citation	Evans, E.J.,Esnouf, R.M.,Manso-Sancho, R.,Gilbert, R.J.C.,James, J.R.,Yu, C.,Fennelly, J.A.,Vowles, C.,Hanke, T.,Walse, B.,Hunig, T.,Sorensen, P.,Stuart, D.I.,Davis, S.J. Crystal structure of a soluble CD28-Fab complex Nat.Immunol., 6:271-279, 2005 Cited by PubMed: 15696168 DOI: 10.1038/ni1170 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation