1YHD

The solution structure of YGGX from Escherichia Coli

1YHD の概要

• エントリーDOI: 10.2210/pdb1yhd/pdb
• 分子名称: UPF0269 protein yggX (1 entity in total)
• 機能のキーワード: helix bundle, unknown function
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12096.74

構造登録者

Osborne, M.J.,Siddiqui, N.,Landgraf, D.,Pomposiello, P.J.,Gehring, K. (登録日: 2005-01-07, 公開日: 2005-01-18, 最終更新日: 2024-05-22)

主引用文献

Osborne, M.J.,Siddiqui, N.,Landgraf, D.,Pomposiello, P.J.,Gehring, K.
The solution structure of the oxidative stress-related protein YggX from Escherichia coli.
Protein Sci., 14:1673-1678, 2005

PubMed Abstract: YggX is a highly conserved protein found only in eubacteria and is proposed to be involved in the bacterial response to oxidative stress. Here we report the solution structure of YggX from Escherichia coli determined by nuclear magnetic resonance spectroscopy. The structure of YggX displays a fold consisting of two N-terminal antiparallel beta-sheets and three alpha-helices, which shares significant structural similarity to the crystal structure of a hypothetical protein PA5148 from Pseudomonas aeruginosa. Previous studies propose YggX as an iron binding protein that is involved in cellular iron trafficking. Our data indicate that the protein alone does not bind iron in vitro, suggesting other cofactors or different conditions may be necessary for metal binding.

PubMed: 15883188
DOI: 10.1110/ps.051358105

実験手法

SOLUTION NMR