1YGS
CRYSTAL STRUCTURE OF THE SMAD4 TUMOR SUPPRESSOR C-TERMINAL DOMAIN
Summary for 1YGS
Entry DOI | 10.2210/pdb1ygs/pdb |
Descriptor | SMAD4 (2 entities in total) |
Functional Keywords | smad4, tumor suppressor c-terminal domain, tgf-beta signal mediator, beta-sandwich scaffold with a three-helix bundle, tumour suppressor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q13485 |
Total number of polymer chains | 1 |
Total formula weight | 25511.09 |
Authors | Shi, Y.,Hata, A.,Lo, R.S.,Massague, J.,Pavletich, N.P. (deposition date: 1997-10-03, release date: 1998-07-08, Last modification date: 2024-02-14) |
Primary citation | Shi, Y.,Hata, A.,Lo, R.S.,Massague, J.,Pavletich, N.P. A structural basis for mutational inactivation of the tumour suppressor Smad4. Nature, 388:87-93, 1997 Cited by PubMed: 9214508DOI: 10.1038/40431 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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