1YGO

Solution Structure of the pelle Death Domain

Summary for 1YGO

• Entry DOI: 10.2210/pdb1ygo/pdb
• Descriptor: Probable serine/threonine-protein kinase pelle (1 entity in total)
• Functional Keywords: anti-parallel 6 helix bundle, transferase
• Biological source: Drosophila melanogaster (fruit fly)
• Cellular location: Cell membrane: Q05652
• Total number of polymer chains: 1
• Total formula weight: 12700.65

Authors

Moncrieffe, M.C.,Stott, K.M.,Gay, N.J. (deposition date: 2005-01-05, release date: 2005-07-26, Last modification date: 2024-05-22)

Primary citation

Moncrieffe, M.C.,Stott, K.M.,Gay, N.J.
Solution structure of the isolated Pelle death domain.
Febs Lett., 579:3920-3926, 2005

PubMed Abstract: The interaction between the death domains (DDs) of Tube and the protein kinase Pelle is an important component of the Toll pathway. Published crystallographic data suggests that the Pelle-Tube DD interface is plastic and implies that in addition to the two predominant Pelle-Tube interfaces, a third interaction is possible. We present the NMR solution structure of the isolated death domain of Pelle and a study of the interaction between the DDs of Pelle and Tube. Our data suggests the solution structure of the isolated Pelle DD is similar to that of Pelle DD in complex with Tube. Additionally, they suggest that the plasticity observed in the crystal structure may not be relevant in the functioning death domain complex.

PubMed: 16004997
DOI: 10.1016/j.febslet.2005.06.009

Experimental method

SOLUTION NMR