1YDS
Structure of CAMP-dependent protein kinase, alpha-catalytic subunit in complex with H8 protein kinase inhibitor [N-(2-methylamino)ethyl]-5-isoquinolinesulfonamide
Summary for 1YDS
Entry DOI | 10.2210/pdb1yds/pdb |
Descriptor | C-AMP-DEPENDENT PROTEIN KINASE, PROTEIN KINASE INHIBITOR PEPTIDE, N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE, ... (4 entities in total) |
Functional Keywords | phosphotransferase, transferase, camp, phosphorylation, isoquinoline sulfonamide, serine/threonine-protein kinase, atp-binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Bos taurus (cattle) |
Cellular location | Cytoplasm: P00517 |
Total number of polymer chains | 2 |
Total formula weight | 43173.10 |
Authors | Engh, R.A.,Girod, A.,Kinzel, V.,Huber, R.,Bossemeyer, D. (deposition date: 1996-07-24, release date: 1997-04-01, Last modification date: 2024-10-09) |
Primary citation | Engh, R.A.,Girod, A.,Kinzel, V.,Huber, R.,Bossemeyer, D. Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity. J.Biol.Chem., 271:26157-26164, 1996 Cited by PubMed: 8824261DOI: 10.1074/jbc.271.42.26157 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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