1YDS

Structure of CAMP-dependent protein kinase, alpha-catalytic subunit in complex with H8 protein kinase inhibitor [N-(2-methylamino)ethyl]-5-isoquinolinesulfonamide

1YDS の概要

• エントリーDOI: 10.2210/pdb1yds/pdb
• 分子名称: C-AMP-DEPENDENT PROTEIN KINASE, PROTEIN KINASE INHIBITOR PEPTIDE, N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE, ... (4 entities in total)
• 機能のキーワード: phosphotransferase, transferase, camp, phosphorylation, isoquinoline sulfonamide, serine/threonine-protein kinase, atp-binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Bos taurus (cattle)
• 細胞内の位置: Cytoplasm: P00517
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43173.10

構造登録者

Engh, R.A.,Girod, A.,Kinzel, V.,Huber, R.,Bossemeyer, D. (登録日: 1996-07-24, 公開日: 1997-04-01, 最終更新日: 2012-02-15)

• 主引用文献: Engh, R.A.,Girod, A.,Kinzel, V.,Huber, R.,Bossemeyer, D.; Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity.; J.Biol.Chem., 271:26157-26164, 1996; PubMed: 8824261; DOI: 10.1074/jbc.271.42.26157

実験手法

X-RAY DIFFRACTION (2.2 Å)