1YDR

STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH H7 PROTEIN KINASE INHIBITOR 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE

1YDR の概要

• エントリーDOI: 10.2210/pdb1ydr/pdb
• 分子名称: C-AMP-DEPENDENT PROTEIN KINASE, PROTEIN KINASE INHIBITOR PEPTIDE, 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE, ... (4 entities in total)
• 機能のキーワード: complex (phosphotransferase-inhibitor), transferase, camp, phosphorylation, isoquinoline sulfonamide, serine/threonine-protein kinase, atp-binding, complex (phosphotransferase-inhibitor) complex, complex (phosphotransferase/inhibitor)
• 由来する生物種: Bos taurus (cattle)
• 細胞内の位置: Cytoplasm: P00517
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43199.14

構造登録者

Engh, R.A.,Girod, A.,Kinzel, V.,Huber, R.,Bossemeyer, D. (登録日: 1996-07-24, 公開日: 1997-04-01, 最終更新日: 2011-07-13)

• 主引用文献: Engh, R.A.,Girod, A.,Kinzel, V.,Huber, R.,Bossemeyer, D.; Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity.; J.Biol.Chem., 271:26157-26164, 1996; PubMed: 8824261; DOI: 10.1074/jbc.271.42.26157

実験手法

X-RAY DIFFRACTION (2.2 Å)