1Y7V

X-ray structure of human acid-beta-glucosidase covalently bound to conduritol B epoxide

1Y7V の概要

• エントリーDOI: 10.2210/pdb1y7v/pdb
• 関連するPDBエントリー: 1OGS
• 分子名称: Glucosylceramidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: gaucher disease, glucosidase, glucocerebrosidase, cerezyme, hydrolase, glycosidase, sphingolipid metabolism, glycoprotein, lysosome, membrane, disease mutation, alternative initiation, israel structural proteomics center, ispc, structural genomics
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 113738.27

構造登録者

Premkumar, L.,Sawkar, A.R.,Boldin-Adamsky, S.,Toker, L.,Silman, I.,Kelly, J.W.,Futerman, A.H.,Sussman, J.L.,Israel Structural Proteomics Center (ISPC) (登録日: 2004-12-10, 公開日: 2005-04-12, 最終更新日: 2023-08-23)

• 主引用文献: Premkumar, L.,Sawkar, A.R.,Boldin-Adamsky, S.,Toker, L.,Silman, I.,Kelly, J.W.,Futerman, A.H.,Sussman, J.L.; X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide. Implications for Gaucher disease.; J.Biol.Chem., 280:23815-23819, 2005; PubMed: 15817452; DOI: 10.1074/jbc.M502799200

実験手法

X-RAY DIFFRACTION (2.4 Å)