1Y6E

Orthorhombic glutathione S-transferase of Schistosoma japonicum

1Y6E の概要

• エントリーDOI: 10.2210/pdb1y6e/pdb
• 分子名称: glutathione S-transferase (2 entities in total)
• 機能のキーワード: dimer, transferase
• 由来する生物種: Schistosoma japonicum
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 52144.58

構造登録者

Rufer, A.C.,Thiebach, L.,Baer, K.,Klein, H.W.,Hennig, M. (登録日: 2004-12-06, 公開日: 2005-03-08, 最終更新日: 2024-03-13)

主引用文献

Rufer, A.C.,Thiebach, L.,Baer, K.,Klein, H.W.,Hennig, M.
X-ray structure of glutathione S-transferase from Schistosoma japonicum in a new crystal form reveals flexibility of the substrate-binding site
Acta Crystallogr.,Sect.F, 61:263-265, 2005

PubMed Abstract: The crystal structure of the 26 kDa glutathione S-transferase from Schistosoma japonicum (SjGST) was determined at 3 A resolution in the new space group P2(1)2(1)2(1). The structure of orthorhombic SjGST reveals unique features of the ligand-binding site and dimer interface when compared with previously reported structures. SjGST is recognized as the major detoxification enzyme of S. japonicum, a pathogenic helminth causing schistosomiasis. As resistance against the established inhibitor of SjGST, praziquantel, has been reported these results might prove to be valuable for the development of novel drugs.

PubMed: 16511012
DOI: 10.1107/S1744309105004823

実験手法

X-RAY DIFFRACTION (3 Å)