1Y2C

Catalytic Domain Of Human Phosphodiesterase 4D In Complex With 3,5-dimethyl-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester

Summary for 1Y2C

Entry DOI	10.2210/pdb1y2c/pdb
Related	1Y2B 1Y2D 1Y2E 1Y2H 1Y2J 1Y2K
Descriptor	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	phosphodiesterase, pde, pde4d, pyrazole, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm (By similarity): Q08499
Total number of polymer chains	2
Total formula weight	82290.30
Authors	Card, G.L.,Blasdel, L.,England, B.P.,Zhang, C.,Suzuki, Y.,Gillette, S.,Fong, D.,Ibrahim, P.N.,Artis, D.R.,Bollag, G.,Milburn, M.V.,Kim, S.-H.,Schlessinger, J.,Zhang, K.Y.J. (deposition date: 2004-11-22, release date: 2005-03-01, Last modification date: 2024-02-14)
Primary citation	Card, G.L.,Blasdel, L.,England, B.P.,Zhang, C.,Suzuki, Y.,Gillette, S.,Fong, D.,Ibrahim, P.N.,Artis, D.R.,Bollag, G.,Milburn, M.V.,Kim, S.-H.,Schlessinger, J.,Zhang, K.Y.J. A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design Nat.Biotechnol., 23:201-207, 2005 Cited by PubMed: 15685167 DOI: 10.1039/nbt1059 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.67 Å)

Structure validation