1XU9

Crystal Structure of the Interface Closed Conformation of 11b-hydroxysteroid dehydrogenase isozyme 1

1XU9 の概要

• エントリーDOI: 10.2210/pdb1xu9/pdb
• 関連するPDBエントリー: 1XU7
• 分子名称: Corticosteroid 11-beta-dehydrogenase, isozyme 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, ... (5 entities in total)
• 機能のキーワード: 11beta, hydroxysteroid, dehydrogenase, sdr, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum membrane; Single-pass type II membrane protein: P28845
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 132983.93

構造登録者

Hosfield, D.J.,Wu, Y.,Skene, R.J.,Hilger, M.,Jennings, A.,Snell, G.P.,Aertgeerts, K. (登録日: 2004-10-25, 公開日: 2004-11-02, 最終更新日: 2024-02-14)

• 主引用文献: Hosfield, D.J.,Wu, Y.,Skene, R.J.,Hilger, M.,Jennings, A.,Snell, G.P.,Aertgeerts, K.; Conformational Flexibility in Crystal Structures of Human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation.; J.Biol.Chem., 280:4639-4648, 2005; PubMed: 15513927; DOI: 10.1074/jbc.M411104200

実験手法

X-RAY DIFFRACTION (1.55 Å)