1XR6

Crystal Structure of RNA-dependent RNA Polymerase 3D from human rhinovirus serotype 1B

「1TE8」から置き換えられました

1XR6 の概要

• エントリーDOI: 10.2210/pdb1xr6/pdb
• 関連するPDBエントリー: 1TE8 1TE9 1TEB 1XR5 1XR7
• 分子名称: Genome polyprotein, POTASSIUM ION (3 entities in total)
• 機能のキーワード: rna-dependent rna polymerase, transferase
• 由来する生物種: Human rhinovirus 1B
• 細胞内の位置: Protein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 2C: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3A: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3B: Virion (Potential). Picornain 3C: Host cytoplasm (Potential). RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential): P12916
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 52408.08

構造登録者

Love, R.A.,Maegley, K.A.,Yu, X.,Ferre, R.A.,Lingardo, L.K.,Diehl, W.,Parge, H.E.,Dragovich, P.S.,Fuhrman, S.A. (登録日: 2004-10-13, 公開日: 2004-10-26, 最終更新日: 2024-02-14)

主引用文献

Love, R.A.,Maegley, K.A.,Yu, X.,Ferre, R.A.,Lingardo, L.K.,Diehl, W.,Parge, H.E.,Dragovich, P.S.,Fuhrman, S.A.
The Crystal Structure of the RNA-Dependent RNA Polymerase from Human Rhinovirus: A Dual-Function Target for Common Cold Antiviral Therapy
Structure, 12:1533-1544, 2004

PubMed Abstract: Human rhinoviruses (HRV), the predominant members of the Picornaviridae family of positive-strand RNA viruses, are the major causative agents of the common cold. Given the lack of effective treatments for rhinoviral infections, virally encoded proteins have become attractive therapeutic targets. The HRV genome encodes an RNA-dependent RNA polymerase (RdRp) denoted 3Dpol, which is responsible for replicating the viral genome and for synthesizing a protein primer used in the replication. Here the crystal structures for three viral serotypes (1B, 14, and 16) of HRV 3Dpol have been determined. The three structures are very similar to one another, and to the closely related poliovirus (PV) 3Dpol enzyme. Because the reported PV crystal structure shows significant disorder, HRV 3Dpol provides the first complete view of a picornaviral RdRp. The folding topology of HRV 3Dpol also resembles that of RdRps from hepatitis C virus (HCV) and rabbit hemorrhagic disease virus (RHDV) despite very low sequence homology.

PubMed: 15296746
DOI: 10.1016/j.str.2004.05.024

実験手法

X-RAY DIFFRACTION (2.5 Å)