1XQG

3.10 A crystal structure of maspin, Space group P 4 21 2

1XQG の概要

• エントリーDOI: 10.2210/pdb1xqg/pdb
• 関連するPDBエントリー: 1XQJ
• 分子名称: Maspin (2 entities in total)
• 機能のキーワード: serpin, maspin, tumor suppression, antitumor protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted, extracellular space: P36952
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 87551.10

構造登録者

Al-Ayyoubi, M.,Gettins, P.G.,Volz, K. (登録日: 2004-10-12, 公開日: 2004-10-26, 最終更新日: 2023-08-23)

主引用文献

Al-Ayyoubi, M.,Gettins, P.G.,Volz, K.
Crystal Structure of Human Maspin, a Serpin with Antitumor Properties: Reactive Center Loop of Mapsin is Exposed but Constrained
J.Biol.Chem., 279:55540-55544, 2004

PubMed Abstract: Maspin, a member of the serpin superfamily, has tumor suppressing activity against breast and prostate cancer. Maspin inhibits tumor growth by blocking cell invasion, and its reactive center loop (RCL) is thought to mediate this activity. To understand this function on the molecular level, we have solved the three-dimensional structure of Maspin to 3.1 A resolution. The molecular structure shows the characteristic features of the serpin fold, but the RCL of Maspin is unique in length, composition, and placement. Although the RCL of Maspin is accessible and cleavable by some proteinases, it functions in the uncleaved, constrained conformation observed here. These structural results will contribute to our understanding of the mechanism by which Maspin suppresses tumors.

PubMed: 15501821
DOI: 10.1074/jbc.M409957200

実験手法

X-RAY DIFFRACTION (3.1 Å)