1XP6

HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 16

1XP6 の概要

• エントリーDOI: 10.2210/pdb1xp6/pdb
• 関連するPDBエントリー: 1XP1 1XP9 1XPC
• 分子名称: Estrogen receptor, (2S,3R)-2-(4-{2-[(3S,4S)-3,4-DIMETHYLPYRROLIDIN-1-YL]ETHOXY}PHENYL)-3-(4-HYDROXYPHENYL)-2,3-DIHYDRO-1,4-BENZOXATHIIN-6-OL (3 entities in total)
• 機能のキーワード: nuclear receptor, transcription factor, er-alpha, antagonist, hormone-growth factor receptor complex, hormone/growth factor receptor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28793.94

構造登録者

Fitzgerald, P.M.D.,Sharma, N. (登録日: 2004-10-08, 公開日: 2004-12-07, 最終更新日: 2024-02-14)

主引用文献

Blizzard, T.A.,Dininno, F.,Morgan, J.D.,Chen, H.Y.,Wu, J.Y.,Kim, S.,Chan, W.,Birzin, E.T.,Yang, Y.T.,Pai, L.Y.,Fitzgerald, P.M.,Sharma, N.,Li, Y.,Zhang, Z.,Hayes, E.C.,Dasilva, C.A.,Tang, W.,Rohrer, S.P.,Schaeffer, J.M.,Hammond, M.L.
Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers.
Bioorg.Med.Chem.Lett., 15:107-113, 2005

PubMed Abstract: A series of dihydrobenzoxathiin SERAMs with alkylated pyrrolidine side chains or alkylated linkers was prepared. Minor modifications in the side chain or linker resulted in significant effects on biological activity, especially in uterine tissue.

PubMed: 15582421
DOI: 10.1016/j.bmcl.2004.10.036

実験手法

X-RAY DIFFRACTION (1.7 Å)