1XOW

Crystal structure of the human androgen receptor ligand binding domain bound with an androgen receptor NH2-terminal peptide, AR20-30, and R1881

Summary for 1XOW

Entry DOI	10.2210/pdb1xow/pdb
Related	1E3G 1I37 1XOW 1XQ2 1XQ3
Descriptor	androgen receptor, decamer fragment of androgen receptor, (17BETA)-17-HYDROXY-17-METHYLESTRA-4,9,11-TRIEN-3-ONE, ... (4 entities in total)
Functional Keywords	crystal structure; human androgen receptor ligand binding domain; androgen receptor nh2-terminal peptide ar20-30; r1881, transcription
Biological source	Homo sapiens (human) More
Cellular location	Nucleus : P10275 P10275
Total number of polymer chains	2
Total formula weight	30597.88
Authors	He, B.,Gampe Jr., R.T.,Kole, A.J.,Hnat, A.T.,Stanley, T.B.,An, G.,Stewart, E.L.,Kalman, R.I.,Minges, J.T.,Wilson, E.M. (deposition date: 2004-10-07, release date: 2004-11-16, Last modification date: 2023-08-23)
Primary citation	He, B.,Gampe Jr., R.T.,Kole, A.J.,Hnat, A.T.,Stanley, T.B.,An, G.,Stewart, E.L.,Kalman, R.I.,Minges, J.T.,Wilson, E.M. Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance Mol.Cell, 16:425-438, 2004 Cited by PubMed: 15525515 DOI: 10.1016/j.molcel.2004.09.036 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation