1XOW

Crystal structure of the human androgen receptor ligand binding domain bound with an androgen receptor NH2-terminal peptide, AR20-30, and R1881

1XOW の概要

• エントリーDOI: 10.2210/pdb1xow/pdb
• 関連するPDBエントリー: 1E3G 1I37 1XOW 1XQ2 1XQ3
• 分子名称: androgen receptor, decamer fragment of androgen receptor, (17BETA)-17-HYDROXY-17-METHYLESTRA-4,9,11-TRIEN-3-ONE, ... (4 entities in total)
• 機能のキーワード: crystal structure; human androgen receptor ligand binding domain; androgen receptor nh2-terminal peptide ar20-30; r1881, transcription
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus : P10275 P10275
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30597.88

構造登録者

He, B.,Gampe Jr., R.T.,Kole, A.J.,Hnat, A.T.,Stanley, T.B.,An, G.,Stewart, E.L.,Kalman, R.I.,Minges, J.T.,Wilson, E.M. (登録日: 2004-10-07, 公開日: 2004-11-16, 最終更新日: 2023-08-23)

• 主引用文献: He, B.,Gampe Jr., R.T.,Kole, A.J.,Hnat, A.T.,Stanley, T.B.,An, G.,Stewart, E.L.,Kalman, R.I.,Minges, J.T.,Wilson, E.M.; Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance; Mol.Cell, 16:425-438, 2004; PubMed: 15525515; DOI: 10.1016/j.molcel.2004.09.036

実験手法

X-RAY DIFFRACTION (1.8 Å)