1XOG

N9 Tern Influenza neuraminidase complexed with a 2,5-Disubstituted tetrahydrofuran-5-carboxylic acid

Summary for 1XOG

• Entry DOI: 10.2210/pdb1xog/pdb
• Related: 1XOE
• Descriptor: Neuraminidase, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose, ... (5 entities in total)
• Functional Keywords: influenza, neuraminidase, tetrahydrofuran inhibitors, hydrolase
• Biological source: Influenza A virus
• Total number of polymer chains: 1
• Total formula weight: 45563.45

Authors

Wang, G.T.,Wang, S.,Gentles, R.,Sowin, T.,Maring, C.J.,Kempf, D.J.,Kati, W.M.,Stoll, V.,Stewart, K.D.,Laver, G. (deposition date: 2004-10-06, release date: 2005-01-11, Last modification date: 2020-07-29)

• Primary citation: Wang, G.T.,Wang, S.,Gentles, R.,Sowin, T.,Maring, C.J.,Kempf, D.J.,Kati, W.M.,Stoll, V.,Stewart, K.D.,Laver, G.; Design, synthesis, and structural analysis of inhibitors of influenza neuraminidase containing a 2,3-disubstituted tetrahydrofuran-5-carboxylic acid core.; Bioorg.Med.Chem.Lett., 15:125-128, 2005; PubMed: 15582424; DOI: 10.1016/j.bmcl.2004.10.022

Experimental method

X-RAY DIFFRACTION (2.8 Å)