1XOG

N9 Tern Influenza neuraminidase complexed with a 2,5-Disubstituted tetrahydrofuran-5-carboxylic acid

1XOG の概要

• エントリーDOI: 10.2210/pdb1xog/pdb
• 関連するPDBエントリー: 1XOE
• 分子名称: Neuraminidase, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose, ... (5 entities in total)
• 機能のキーワード: influenza, neuraminidase, tetrahydrofuran inhibitors, hydrolase
• 由来する生物種: Influenza A virus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45563.45

構造登録者

Wang, G.T.,Wang, S.,Gentles, R.,Sowin, T.,Maring, C.J.,Kempf, D.J.,Kati, W.M.,Stoll, V.,Stewart, K.D.,Laver, G. (登録日: 2004-10-06, 公開日: 2005-01-11, 最終更新日: 2020-07-29)

• 主引用文献: Wang, G.T.,Wang, S.,Gentles, R.,Sowin, T.,Maring, C.J.,Kempf, D.J.,Kati, W.M.,Stoll, V.,Stewart, K.D.,Laver, G.; Design, synthesis, and structural analysis of inhibitors of influenza neuraminidase containing a 2,3-disubstituted tetrahydrofuran-5-carboxylic acid core.; Bioorg.Med.Chem.Lett., 15:125-128, 2005; PubMed: 15582424; DOI: 10.1016/j.bmcl.2004.10.022

実験手法

X-RAY DIFFRACTION (2.8 Å)