1XKK

EGFR kinase domain complexed with a quinazoline inhibitor- GW572016

1XKK の概要

• エントリーDOI: 10.2210/pdb1xkk/pdb
• 分子名称: Epidermal growth factor receptor, PHOSPHATE ION, N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE, ... (4 entities in total)
• 機能のキーワード: egfr, epidermal growth factor receptor, kinase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41095.41

構造登録者

Wood, E.R.,Truesdale, A.T.,McDonald, O.B.,Yuan, D.,Hassell, A.,Dickerson, S.H.,Ellis, B.,Pennisi, C.,Horne, E.,Lackey, K.,Alligood, K.J.,Rusnak, D.W.,Gilmer, T.M.,Shewchuk, L.M. (登録日: 2004-09-29, 公開日: 2004-12-07, 最終更新日: 2023-08-23)

• 主引用文献: Wood, E.R.,Truesdale, A.T.,McDonald, O.B.,Yuan, D.,Hassell, A.,Dickerson, S.H.,Ellis, B.,Pennisi, C.,Horne, E.,Lackey, K.,Alligood, K.J.,Rusnak, D.W.,Gilmer, T.M.,Shewchuk, L.; A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells.; Cancer Res., 64:6652-6659, 2004; PubMed: 15374980; DOI: 10.1158/0008-5472.CAN-04-1168

実験手法

X-RAY DIFFRACTION (2.4 Å)