1XIO

Anabaena sensory rhodopsin

1XIO の概要

• エントリーDOI: 10.2210/pdb1xio/pdb
• 分子名称: ANABAENA SENSORY RHODOPSIN, RETINAL, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, ... (4 entities in total)
• 機能のキーワード: signaling protein, photoreceptor
• 由来する生物種: Nostoc sp. PCC 7120
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40173.05

構造登録者

Vogeley, L.,Luecke, H. (登録日: 2004-09-21, 公開日: 2004-10-05, 最終更新日: 2023-08-23)

主引用文献

Vogeley, L.,Sineshchekov, O.A.,Trivedi, V.D.,Sasaki, J.,Spudich, J.L.,Luecke, H.
Anabaena sensory rhodopsin: a photochromic color sensor at 2.0 A.
Science, 306:1390-1393, 2004

PubMed Abstract: Microbial sensory rhodopsins are a family of membrane-embedded photoreceptors in prokaryotic and eukaryotic organisms. Structures of archaeal rhodopsins, which function as light-driven ion pumps or photosensors, have been reported. We present the structure of a eubacterial rhodopsin, which differs from those of previously characterized archaeal rhodopsins in its chromophore and cytoplasmic-side portions. Anabaena sensory rhodopsin exhibits light-induced interconversion between stable 13-cis and all-trans states of the retinylidene protein. The ratio of its cis and trans chromophore forms depends on the wavelength of illumination, thus providing a mechanism for a single protein to signal the color of light, for example, to regulate color-sensitive processes such as chromatic adaptation in photosynthesis. Its cytoplasmic half channel, highly hydrophobic in the archaeal rhodopsins, contains numerous hydrophilic residues networked by water molecules, providing a connection from the photoactive site to the cytoplasmic surface believed to interact with the receptor's soluble 14-kilodalton transducer.

PubMed: 15459346
DOI: 10.1126/science.1103943

実験手法

X-RAY DIFFRACTION (2 Å)