1XHA

Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants

Summary for 1XHA

Entry DOI	10.2210/pdb1xha/pdb
Related	1SVE 1SVG 1SVH 1VEB 1XH4 1XH5 1XH6 1XH7 1XH8 1XH9
Descriptor	cAMP-dependent protein kinase, alpha-catalytic subunit, cAMP-dependent protein kinase inhibitor, alpha form, N-{4-[(4-{3-[(2R)-3,3-DIMETHYLPIPERIDIN-2-YL]-2-FLUORO-6-HYDROXYBENZOYL}BENZOYL)AMINO]AZEPAN-3-YL}ISONICOTINAMIDE, ... (4 entities in total)
Functional Keywords	pka, kinase-inhibitor-complex, serine/threonine-protein kinase, balanol derivative, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Bos taurus (cattle) More
Cellular location	Cytoplasm: P00517
Total number of polymer chains	2
Total formula weight	43477.47
Authors	Breitenlechner, C.B.,Friebe, W.-G.,Brunet, E.,Werner, G.,Graul, K.,Thomas, U.,Kuenkele, K.-P.,Schaefer, W.,Gassel, M.,Bossemeyer, D.,Huber, R.,Engh, R.A.,Masjost, B. (deposition date: 2004-09-17, release date: 2005-09-17, Last modification date: 2021-11-10)
Primary citation	Breitenlechner, C.B.,Friebe, W.-G.,Brunet, E.,Werner, G.,Graul, K.,Thomas, U.,Kuenkele, K.-P.,Schaefer, W.,Gassel, M.,Bossemeyer, D.,Huber, R.,Engh, R.A.,Masjost, B. Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants J.Med.Chem., 48:163-170, 2005 Cited by PubMed: 15634010 DOI: 10.1021/jm049701n PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.46 Å)

Structure validation