1X8B

Structure of human Wee1A kinase: kinase domain complexed with inhibitor PD0407824

1X8B の概要

• エントリーDOI: 10.2210/pdb1x8b/pdb
• 分子名称: Wee1-like protein kinase, MAGNESIUM ION, 9-HYDROXY-4-PHENYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE, ... (4 entities in total)
• 機能のキーワード: kinase, cell cycle, wee1, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P30291
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32861.95

構造登録者

Squire, C.J.,Dickson, J.M.,Ivanovic, I.,Baker, E.N. (登録日: 2004-08-17, 公開日: 2005-06-07, 最終更新日: 2024-03-13)

• 主引用文献: Squire, C.J.,Dickson, J.M.,Ivanovic, I.,Baker, E.N.; Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation; Structure, 13:541-550, 2005; PubMed: 15837193; DOI: 10.1016/j.str.2004.12.017

実験手法

X-RAY DIFFRACTION (1.81 Å)