1WZ9

The 2.1 A structure of a tumour suppressing serpin

Summary for 1WZ9

• Entry DOI: 10.2210/pdb1wz9/pdb
• Related: 1XU8
• Descriptor: Maspin precursor, SULFATE ION (3 entities in total)
• Functional Keywords: maspin, serpin, tumor suppressor, serpinb5, signaling protein
• Biological source: Homo sapiens (human)
• Cellular location: Secreted, extracellular space: P36952
• Total number of polymer chains: 2
• Total formula weight: 85362.02

Authors

Law, R.H.,Irving, J.A.,Buckle, A.M.,Ruzyla, K.,Buzza, M.,Bashtannyk-Puhalovich, T.A.,Beddoe, T.C.,Kim, N.,Worrall, D.M.,Bottomley, S.P.,Bird, P.I.,Rossjohn, J.,Whisstock, J.C. (deposition date: 2005-03-03, release date: 2005-03-15, Last modification date: 2023-10-25)

• Primary citation: Law, R.H.,Irving, J.A.,Buckle, A.M.,Ruzyla, K.,Buzza, M.,Bashtannyk-Puhalovich, T.A.,Beddoe, T.C.,Nguyen, K.,Worrall, D.M.,Bottomley, S.P.,Bird, P.I.,Rossjohn, J.,Whisstock, J.C.; The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix.; J.Biol.Chem., 280:22356-22364, 2005; PubMed: 15760906; DOI: 10.1074/jbc.M412043200

Experimental method

X-RAY DIFFRACTION (2.1 Å)