1WV7

Human Factor Viia-Tissue Factor Complexed with ethylsulfonamide-D-5-propoxy-Trp-Gln-p-aminobenzamidine

1WV7 の概要

• エントリーDOI: 10.2210/pdb1wv7/pdb
• 関連するPDBエントリー: 1DAN 1WQV 1WSS 1WTG 1WUN
• 分子名称: Coagulation factor VII, Tissue factor, beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: serine protease, hydrolase-blood clotting complex, hydrolase/blood clotting
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 71606.47

構造登録者

Kadono, S.,Sakamoto, A.,Kikuchi, Y.,Oh-eda, M.,Yabuta, N.,Yoshihashi, K.,Kitazawa, T.,Suzuki, T.,Koga, T.,Hattori, K.,Shiraishi, T.,Haramura, M.,Kodama, H.,Ono, Y.,Esaki, T.,Sato, H.,Watanabe, Y.,Itoh, S.,Ohta, M.,Kozono, T. (登録日: 2004-12-11, 公開日: 2005-12-11, 最終更新日: 2025-03-26)

主引用文献

Kadono, S.,Sakamoto, A.,Kikuchi, Y.,Oh-eda, M.,Yabuta, N.,Yoshihashi, K.,Kitazawa, T.,Suzuki, T.,Koga, T.,Hattori, K.,Shiraishi, T.,Haramura, M.,Kodama, H.,Ono, Y.,Esaki, T.,Sato, H.,Watanabe, Y.,Itoh, S.,Ohta, M.,Kozono, T.
Structure-based design of P3 moieties in the peptide mimetic factor VIIa inhibitor
Biochem.Biophys.Res.Commun., 327:589-596, 2005

PubMed Abstract: Selective factor VIIa-tissue factor complex (FVIIa/TF) inhibition is seen as a promising target for developing new anticoagulant drugs. Structure-based designs of the P3 moiety in the peptide mimetic factor VIIa inhibitor successfully lead to novel inhibitors with selectivity for FVIIa/TF and extrinsic coagulation the same as or even higher than those of previously reported peptide mimetic factor VIIa inhibitors. X-ray crystal structure analysis reveals that one of the novel inhibitors shows improved selectivity by forming interactions between the inhibitor and FVIIa as expected. Another of the novel inhibitors achieves improved selectivity through an unexpected hydrogen bond with Gln217, with a unique bent conformation in FVIIa/TF accompanied by conformational changes of the inhibitor and the protein.

PubMed: 15629154
DOI: 10.1016/j.bbrc.2004.12.042

実験手法

X-RAY DIFFRACTION (2.7 Å)