1WV0

Crystallographic studies on acyl ureas, a new class of inhibitors of glycogen phosphorylase. Broad specificity of the allosteric site

1WV0 の概要

• エントリーDOI: 10.2210/pdb1wv0/pdb
• 関連するPDBエントリー: 1WUT 1WV1 1WVY 3AMV
• 分子名称: Glycogen phosphorylase, muscle form, PYRIDOXAL-5'-PHOSPHATE, 4-[4-({[(2,4-DICHLOROBENZOYL)AMINO]CARBONYL}AMINO)-2,3-DIMETHYLPHENOXY]BUTANOIC ACID, ... (4 entities in total)
• 機能のキーワード: glycogenolysis, type 2 diabetes, transferase
• 由来する生物種: Oryctolagus cuniculus (rabbit)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 97977.63

構造登録者

Oikonomakos, N.G.,Kosmopoulou, M.N.,Chrysina, E.D.,Leonidas, D.D.,Klabunde, T.,Wendt, K.U.,Defossa, E. (登録日: 2004-12-10, 公開日: 2005-12-10, 最終更新日: 2011-07-13)

• 主引用文献: Oikonomakos, N.G.,Kosmopoulou, M.N.,Chrysina, E.D.,Leonidas, D.D.,Kostas, I.D.,Wendt, K.U.,Klabunde, T.,Defossa, E.; Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs; Protein Sci., 14:1760-1771, 2005; PubMed: 15987904; DOI: 10.1110/ps.051432405

実験手法

X-RAY DIFFRACTION (2.26 Å)