1WCY

Crystal Structure Of Human Dipeptidyl Peptidase IV (DPPIV) Complex With Diprotin A

1WCY の概要

• エントリーDOI: 10.2210/pdb1wcy/pdb
• 分子名称: Dipeptidyl peptidase IV, Diprotin A, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: serine protease, dipeptidyl peptidase iv, cd26, prolyl oligopeptidase, beta-propeller structure, diprotin a, hydrolase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 176405.70

構造登録者

Hiramatsu, H.,Yamamoto, A.,Kyono, K.,Higashiyama, Y.,Fukushima, C.,Shima, H.,Sugiyama, S.,Inaka, K.,Shimizu, R. (登録日: 2004-05-07, 公開日: 2005-05-07, 最終更新日: 2023-10-25)

主引用文献

Hiramatsu, H.,Yamamoto, A.,Kyono, K.,Higashiyama, Y.,Fukushima, C.,Shima, H.,Sugiyama, S.,Inaka, K.,Shimizu, R.
The crystal structure of human dipeptidyl peptidase IV (DPPIV) complex with diprotin A
Biol.Chem., 385:561-564, 2004

PubMed Abstract: Dipeptidyl peptidase IV (DPPIV) is a serine protease, a member of the prolyl oligopeptidase (POP) family, and has been implicated in several diseases. Therefore, it seems important to develop selective inhibitors for human DPPIV (hDPPIV) that are able to control the biological function of hDPPIV. In order to elucidate the binding mode and substrate specificity, we determined the crystal structure complex of hDPPIV and diprotin A (IIe-Pro-IIe), a slowly hydrolyzed substrate of hDPPIV, at 2.2 A resolution. In this paper, we discuss the molecular interaction mechanism of diprotin A with hDPPIV based on the X-ray crystal structure.

PubMed: 15255191
DOI: 10.1515/BC.2004.068

実験手法

X-RAY DIFFRACTION (2.2 Å)