1WCT

A NOVEL CONOTOXIN FROM CONUS TEXTILE WITH UNUSUAL POST-TRANSLATIONAL MODIFICATIONS REDUCES PRESYNAPTIC CALCIUM INFLUX, NMR, 1 STRUCTURE, GLYCOSYLATED PROTEIN

1WCT の概要

• エントリーDOI: 10.2210/pdb1wct/pdb
• 分子名称: OMEGAC-TXIX, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose (2 entities in total)
• 機能のキーワード: gamma-carboxy glutamic acid, novel omega conotoxin, calcium channel blocker
• 由来する生物種: Conus textile (cloth-of-gold cone)
• 細胞内の位置: Secreted: P81755
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 1953.80

構造登録者

Rigby, A.C.,Hambe, B.,Czerwiec, E.,Baleja, J.D.,Furie, B.C.,Furie, B.,Stenflo, J. (登録日: 1998-12-18, 公開日: 1999-06-08, 最終更新日: 2020-07-29)

• 主引用文献: Rigby, A.C.,Lucas-Meunier, E.,Kalume, D.E.,Czerwiec, E.,Hambe, B.,Dahlqvist, I.,Fossier, P.,Baux, G.,Roepstorff, P.,Baleja, J.D.,Furie, B.C.,Furie, B.,Stenflo, J.; A conotoxin from Conus textile with unusual posttranslational modifications reduces presynaptic Ca2+ influx.; Proc.Natl.Acad.Sci.USA, 96:5758-5763, 1999; PubMed: 10318957; DOI: 10.1073/pnas.96.10.5758

実験手法

SOLUTION NMR