1W96

Crystal Structure of Biotin Carboxylase Domain of Acetyl-coenzyme A Carboxylase from Saccharomyces cerevisiae in Complex with Soraphen A

1W96 の概要

• エントリーDOI: 10.2210/pdb1w96/pdb
• 関連するPDBエントリー: 1OD2 1OD4 1UYR 1UYS 1UYT 1UYV 1W2X 1W93
• 分子名称: ACETYL-COENZYME A CARBOXYLASE, SORAPHEN A (3 entities in total)
• 機能のキーワード: ligase, obesity, diabetes, fatty acid metabolism, structure-based drug design, allosteric inhibition, polyketide
• 由来する生物種: SACCHAROMYCES CEREVISIAE (BAKER'S YEAST)
• 細胞内の位置: Cytoplasm: Q00955
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 186519.02

構造登録者

Shen, Y.,Volrath, S.L.,Weatherly, S.C.,Elich, T.D.,Tong, L. (登録日: 2004-10-06, 公開日: 2005-01-04, 最終更新日: 2011-07-13)

• 主引用文献: Shen, Y.,Volrath, S.L.,Weatherly, S.C.,Elich, T.D.,Tong, L.; A Mechanism for the Potent Inhibition of Eukaryotic Acetyl-Coenzyme a Carboxylase by Soraphen A, a Macrocyclic Polyketide Natural Product; Mol.Cell, 16:881-, 2004; PubMed: 15610732; DOI: 10.1016/J.MOLCEL.2004.11.034

実験手法

X-RAY DIFFRACTION (1.8 Å)