1W31
YEAST 5-AMINOLAEVULINIC ACID DEHYDRATASE 5-HYDROXYLAEVULINIC ACID COMPLEX
Summary for 1W31
| Entry DOI | 10.2210/pdb1w31/pdb |
| Related | 1AW5 1EB3 1GJP 1H7N 1H7O 1H7P 1H7R 1OHL 1QML 1QNV 1YLV |
| Descriptor | DELTA-AMINOLEVULINIC ACID DEHYDRATASE, 5-HYDROXYLAEVULINIC ACID, ZINC ION, ... (4 entities in total) |
| Functional Keywords | dehydratase, aldolase, tim barrel, tetrapyrrole synthesis, heme biosynthesis, lyase, zinc |
| Biological source | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) |
| Total number of polymer chains | 1 |
| Total formula weight | 37968.70 |
| Authors | Erskine, P.T.,Coates, L.,Newbold, R.,Brindley, A.A.,Stauffer, F.,Beaven, G.D.E.,Gill, R.,Wood, S.P.,Warren, M.J.,Cooper, J.B.,Shoolingin-Jordan, P.M.,Neier, R. (deposition date: 2004-07-11, release date: 2005-08-23, Last modification date: 2024-10-23) |
| Primary citation | Erskine, P.T.,Coates, L.,Newbold, R.,Brindley, A.A.,Stauffer, F.,Beaven, G.D.E.,Gill, R.,Coker, A.,Wood, S.P.,Warren, M.J.,Shoolingin-Jordan, P.M.,Neier, R.,Cooper, J.B. Structure of Yeast 5-Aminolaevulinic Acid Dehydratase Complexed with the Inhibitor 5-Hydroxylaevulinic Acid Acta Crystallogr.,Sect.D, 61:1222-, 2005 Cited by PubMed Abstract: The X-ray structure of the enzyme 5-aminolaevulinic acid dehydratase (ALAD) from yeast complexed with the competitive inhibitor 5-hydroxylaevulinic acid has been determined at a resolution of 1.9 A. The structure shows that the inhibitor is bound by a Schiff-base link to one of the invariant active-site lysine residues (Lys263). The inhibitor appears to bind in two well defined conformations and the interactions made by it suggest that it is a very close analogue of the substrate 5-aminolaevulinic acid (ALA). PubMed: 16131755DOI: 10.1107/S0907444905018834 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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