1VZK
A Thiophene Based Diamidine Forms a "Super" AT Binding Minor Groove Agent
Summary for 1VZK
Entry DOI | 10.2210/pdb1vzk/pdb |
Related | 2DBE |
Descriptor | 5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP *CP*G)-3', 2-(5-{4-[AMINO(IMINO)METHYL]PHENYL}-2-THIENYL)-1H-BENZIMIDAZOLE-6- CARBOXIMIDAMIDE DIHYDROCHLORIDE, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | nucleic acid, nucleic acids, minor groove binder, double helix, dna-drug complex, magnesium-water complex, dna hydration |
Total number of polymer chains | 2 |
Total formula weight | 7711.52 |
Authors | Mallena, S.,Lee, M.P.H.,Bailly, C.,Neidle, S.,Kumar, A.,Boykin, D.W.,Wilson, W.D. (deposition date: 2004-05-20, release date: 2004-10-25, Last modification date: 2023-12-13) |
Primary citation | Mallena, S.,Lee, M.P.H.,Bailly, C.,Neidle, S.,Kumar, A.,Boykin, D.W.,Wilson, W.D. Thiophene-Based Diamidine Forms a "Super" at Binding Minor Groove Agent J.Am.Chem.Soc., 142:13659-, 2004 Cited by PubMed: 15493923DOI: 10.1021/JA048175M PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.77 Å) |
Structure validation
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