1VZK

A Thiophene Based Diamidine Forms a "Super" AT Binding Minor Groove Agent

Summary for 1VZK

• Entry DOI: 10.2210/pdb1vzk/pdb
• Related: 2DBE
• Descriptor: 5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP *CP*G)-3', 2-(5-{4-[AMINO(IMINO)METHYL]PHENYL}-2-THIENYL)-1H-BENZIMIDAZOLE-6- CARBOXIMIDAMIDE DIHYDROCHLORIDE, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: nucleic acid, nucleic acids, minor groove binder, double helix, dna-drug complex, magnesium-water complex, dna hydration
• Total number of polymer chains: 2
• Total formula weight: 7711.52

Authors

Mallena, S.,Lee, M.P.H.,Bailly, C.,Neidle, S.,Kumar, A.,Boykin, D.W.,Wilson, W.D. (deposition date: 2004-05-20, release date: 2004-10-25, Last modification date: 2023-12-13)

• Primary citation: Mallena, S.,Lee, M.P.H.,Bailly, C.,Neidle, S.,Kumar, A.,Boykin, D.W.,Wilson, W.D.; Thiophene-Based Diamidine Forms a "Super" at Binding Minor Groove Agent; J.Am.Chem.Soc., 142:13659-, 2004; PubMed: 15493923; DOI: 10.1021/JA048175M

Experimental method

X-RAY DIFFRACTION (1.77 Å)