1VTV

Molecular structure of (M5DC-DG)3: The role of the methyl group on 5-methyl cytosine in stabilizing Z-DNA

1VTV の概要

• エントリーDOI: 10.2210/pdb1vtv/pdb
• 分子名称: DNA (5'-D(*(CH3)CP*GP*(CH3)CP*GP*(CH3)CP*G)-3') (1 entity in total)
• 機能のキーワード: z-dna, double helix, modified, dna
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 3704.57

構造登録者

Fujii, S.,Wang, A.H.-J.,Van Der Marel, G.A.,Van Boom, J.H.,Rich, A. (登録日: 1989-01-10, 公開日: 2011-07-13, 最終更新日: 2023-12-27)

主引用文献

Fujii, S.,Wang, A.H.-J.,Van Der Marel, G.A.,Van Boom, J.H.,Rich, A.
Molecular Structure of (m5dC-dG)3: The Role of the Methyl Group on 5-Methyl Cytosine in Stabilizing Z-DNA
Nucleic Acids Res., 10:7879-7892, 1982

PubMed Abstract: The hexamer (m5 dC-dG)3 has been synthesized and its three-dimensional structure determined by a single crystal X-ray diffraction analysis. The structure has been refined to a final R value of 15.6% at 1.3 A resolution. The molecule forms a left-handed Z-DNA helix which is similar to the unmethylated Z-DNA structure. The presence of the methyl group has resulted in slight changes in the twist angle between successive base pairs and modification of some of the interatomic contacts. Methylation of cytosine in the C5 position is associated with a relative destabilization of the B-DNA structure and a stabilization through hydrophobic bonding of the Z-DNA structure.

PubMed: 7155900

実験手法

X-RAY DIFFRACTION (1.3 Å)