1VR2
HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (KDR) KINASE DOMAIN
Summary for 1VR2
Entry DOI | 10.2210/pdb1vr2/pdb |
Descriptor | PROTEIN (VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR KINASE) (2 entities in total) |
Functional Keywords | tyrosine kinase, transferase |
Biological source | Homo sapiens (human) More |
Cellular location | Cell junction . Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted . Isoform 3: Secreted: P35968 |
Total number of polymer chains | 1 |
Total formula weight | 36274.74 |
Authors | Mctigue, M.,Wickersham, J.,Pinko, C.,Showalter, R.,Parast, C.,Tempczyk-Russell, A.,Gehring, M.,Mroczkowski, B.,Kan, C.,Villafranca, J.,Appelt, K. (deposition date: 1998-12-03, release date: 2000-03-15, Last modification date: 2023-11-15) |
Primary citation | McTigue, M.A.,Wickersham, J.A.,Pinko, C.,Showalter, R.E.,Parast, C.V.,Tempczyk-Russell, A.,Gehring, M.R.,Mroczkowski, B.,Kan, C.C.,Villafranca, J.E.,Appelt, K. Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis. Structure Fold.Des., 7:319-330, 1999 Cited by PubMed: 10368301DOI: 10.1016/S0969-2126(99)80042-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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