1VR2

HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (KDR) KINASE DOMAIN

1VR2 の概要

• エントリーDOI: 10.2210/pdb1vr2/pdb
• 分子名称: PROTEIN (VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR KINASE) (2 entities in total)
• 機能のキーワード: tyrosine kinase, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell junction . Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted . Isoform 3: Secreted: P35968
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36274.74

構造登録者

Mctigue, M.,Wickersham, J.,Pinko, C.,Showalter, R.,Parast, C.,Tempczyk-Russell, A.,Gehring, M.,Mroczkowski, B.,Kan, C.,Villafranca, J.,Appelt, K. (登録日: 1998-12-03, 公開日: 2000-03-15, 最終更新日: 2024-11-20)

主引用文献

McTigue, M.A.,Wickersham, J.A.,Pinko, C.,Showalter, R.E.,Parast, C.V.,Tempczyk-Russell, A.,Gehring, M.R.,Mroczkowski, B.,Kan, C.C.,Villafranca, J.E.,Appelt, K.
Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis.
Structure Fold.Des., 7:319-330, 1999

PubMed Abstract: Angiogenesis is involved in tumor growth, macular degeneration, retinopathy and other diseases. Vascular endothelial growth factor (VEGF) stimulates angiogenesis by binding to specific receptors (VEGFRs) on the surface of vascular endothelial cells. VEGFRs are receptor tyrosine kinases that, like the platelet-derived growth factor receptors (PDGFRs), contain a large insert within the kinase domain.

PubMed: 10368301
DOI: 10.1016/S0969-2126(99)80042-2

実験手法

X-RAY DIFFRACTION (2.4 Å)