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1VJY

Crystal Structure of a Naphthyridine Inhibitor of Human TGF-beta Type I Receptor

Summary for 1VJY
Entry DOI10.2210/pdb1vjy/pdb
DescriptorTGF-beta receptor type I, 2-[5-(6-METHYLPYRIDIN-2-YL)-2,3-DIHYDRO-1H-PYRAZOL-4-YL]-1,5-NAPHTHYRIDINE (3 entities in total)
Functional Keywordstransferase, protein kinase, inhibitor complex
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein: P36897
Total number of polymer chains1
Total formula weight35013.33
Authors
Primary citationGellibert, F.,Woolven, J.,Fouchet, M.-H.,Mathews, N.,Goodland, H.,Lovegrove, V.,Laroze, A.,Nguyen, V.-L.,Sautet, S.,Wang, R.,Janson, C.,Smith, W.,Krysa, G.,Boullay, V.,De Gouville, A.-C.,Huet, S.,Hartley, D.
Identification of 1,5-Naphthyridine Derivatives as a Novel Series of Potent and Selective TGF-beta Type I Receptor Inhibitors.
J.Med.Chem., 47:4494-4506, 2004
Cited by
PubMed: 15317461
DOI: 10.1021/jm0400247
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

221051

건을2024-06-12부터공개중

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