1VIJ

HIV-1 PROTEASE COMPLEXED WITH THE INHIBITOR HOE/BAY 793 HEXAGONAL FORM

1VIJ の概要

• エントリーDOI: 10.2210/pdb1vij/pdb
• 分子名称: HIV-1 PROTEASE, N-(1-BENZYL-2,3-DIHYDROXY-4-{3-METHYL-2-[2-(2-METHYL-PROPANE-2-SULFONYLMETHYL)-3-NAPHTHALEN-1-YL-PROPIONYLAMINO]-BUTYRYLAMINO}-5-PHENYL-PENTYL)-3-METHYL-2-[2-(2-METHYL-PROPANE-2-SULFONYLMETHYL)-3-NAPHTHALEN-1-YL-PROPIONYLAMINO]-BUTYRAMIDE (3 entities in total)
• 機能のキーワード: aspartyl protease, human immunodeficiency virus, hoe/bay 793: inhibitor design
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P12499
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22793.05

構造登録者

Lange-Savage, G.,Berchtold, H.,Liesum, A.,Hilgenfeld, R. (登録日: 1997-05-07, 公開日: 1999-01-13, 最終更新日: 2024-02-14)

• 主引用文献: Lange-Savage, G.,Berchtold, H.,Liesum, A.,Budt, K.H.,Peyman, A.,Knolle, J.,Sedlacek, J.,Fabry, M.,Hilgenfeld, R.; Structure of HOE/BAY 793 complexed to human immunodeficiency virus (HIV-1) protease in two different crystal forms--structure/function relationship and influence of crystal packing.; Eur.J.Biochem., 248:313-322, 1997; PubMed: 9346283; DOI: 10.1111/j.1432-1033.1997.00313.x

実験手法

X-RAY DIFFRACTION (2.4 Å)